黑热病后皮肤利什曼病：一项临床与治疗研究。
Post-kala-azar dermal leishmaniasis: a clinical and therapeutic study.
作者信息
Ramesh V, Misra R S, Saxena U, Mukherjee A
机构信息
Department of Dermatology and Leprology, Safdarjang Hospital, New Delhi, India.
出版信息
Int J Dermatol. 1993 Apr;32(4):272-5. doi: 10.1111/j.1365-4362.1993.tb04266.x.
BACKGROUND
Post-kala-azar dermal leishmaniasis is a condition peculiarly confined to the Indian subcontinent.
METHODS
The clinical features and investigations in 18 patients of post-kala-azar dermal leishmaniasis were studied.
RESULTS
There was a polymorphic picture from hypopigmented macules to nodules and plaques. Mucous membranes were affected in five, the lips and glans penis being the most frequent sites. Histopathologically, a rich dermal infiltrate was seen in indurated lesions and in macules; it was confined to perivascular foci in the upper dermis. Leishman-Donovan bodies were seen in 16.
CONCLUSIONS
The lesions cleared in 4 to 5 months after treatment with sodium antimony gluconate intramuscularly 20 mg/kg/day up to a maximum of 1 g/day. The drug was well tolerated.
背景
黑热病后皮肤利什曼病是一种特别局限于印度次大陆的病症。
方法
对18例黑热病后皮肤利什曼病患者的临床特征及检查进行了研究。
结果
出现了从色素减退斑到结节和斑块的多形性表现。5例患者的黏膜受累，嘴唇和阴茎头是最常见的部位。组织病理学上，在硬结性病变和斑片中可见丰富的真皮浸润；局限于真皮上层的血管周围病灶。16例可见利什曼-多诺万小体。
结论
用葡萄糖酸锑钠每日20mg/kg肌肉注射，最大剂量为每日1g治疗后，皮损在4至5个月内消退。该药物耐受性良好。
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