Serafin M, Khateb A, Vibert N, Vidal P P, Mühlethaler M
Département de Physiologie, CMU, Geneva, Switzerland.
Exp Brain Res. 1993;93(2):242-8. doi: 10.1007/BF00228391.
Antihistaminergic drugs are currently used for the symptomatic treatment of vestibular-related syndromes such as vertigo and motion sickness. We therefore investigated whether histamine could modulate the firing of medial vestibular nuclei neurons (MVNn). Recently, we have demonstrated that different cell types are present among MVNn in guinea-pig brainstem slices. Bath-application of histamine at 10(-4) or 10(-5) M induced a small membrane depolarization accompanied by a slight decrease in membrane resistance and a reversible increase in spontaneous firing in all MVN cell types. These effects were presumably postsynaptic as they persisted in a low-calcium/high-magnesium solution. Using a variety of agonists and antagonists of histamine receptors (H1, H2 and H3), we conclude that these effects are mediated by H2 receptors. The companion paper is concerned with an in vivo study of the histaminergic modulation of the vestibular function (Yabe et al., in press).
抗组胺能药物目前用于对症治疗与前庭相关的综合征，如眩晕和晕动病。因此，我们研究了组胺是否能调节内侧前庭核神经元（MVNn）的放电。最近，我们已经证明豚鼠脑干切片中的MVNn存在不同的细胞类型。在10^(-4)或10^(-5) M浓度下浴用组胺会引起轻微的膜去极化，同时膜电阻略有降低，并且所有MVN细胞类型的自发放电均出现可逆性增加。这些效应可能是突触后效应，因为它们在低钙/高镁溶液中仍然存在。使用多种组胺受体（H1、H2和H3）的激动剂和拮抗剂，我们得出结论，这些效应是由H2受体介导的。配套论文关注组胺能对前庭功能的体内研究（矢部等人，即将发表）。
