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采用气液色谱法和质量碎片谱法测定血样中的罂粟碱。

Determination of papaverine in blood samples by gas-liquid chromatography and mass fragmentography.

作者信息

de Graeve J, Cantfort J V, Gielen J

出版信息

J Chromatogr. 1977 Mar 11;133(1):153-60. doi: 10.1016/s0021-9673(00)89215-8.

DOI:10.1016/s0021-9673(00)89215-8
PMID:838795
Abstract

The measurement of papaverine in blood samples by using either a glass capillary column with a flame-ionization detector or a packed column with mass fragmentographic detection is described. The two methods permit the determination of the normal range of concentrations of papaverine in blood (2-500 ng/ml). Owing to its high specificity, mass fragmentography is greatly superior to capillary chromatography, which is sometimes subject to interferences by solvent impurities.

摘要

描述了使用带有火焰离子化检测器的玻璃毛细管柱或带有质量碎片谱检测的填充柱来测量血样中罂粟碱的方法。这两种方法可测定血液中罂粟碱的正常浓度范围(2 - 500纳克/毫升)。由于其高特异性,质量碎片谱法大大优于毛细管色谱法,毛细管色谱法有时会受到溶剂杂质的干扰。

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