Young E A, Neff N H, Hadjiconstantinou M
Neuroscience Program, Ohio State University College of Medicine, Columbus.
J Neurochem. 1993 Jun;60(6):2331-3. doi: 10.1111/j.1471-4159.1993.tb03525.x.
Aromatic L-amino acid decarboxylase (AAAD) activity of mouse striatum and midbrain increased after an intracerebroventricular injection of either forskolin or 8-bromo-cyclic AMP. The increase was transient, peaking between 15 and 30 min and returning to baseline by approximately 90 min. The increase of AAAD activity after forskolin was not affected by pretreatment with cycloheximide. Kinetic studies indicated an apparent increase of Vmax with little change of the Km for L-DOPA or pyridoxal 5'-phosphate. We conclude that AAAD activity of striatum and midbrain can be modulated by a cyclic AMP-dependent process.
脑室注射福斯高林或8-溴环磷酸腺苷后，小鼠纹状体和中脑的芳香族L-氨基酸脱羧酶（AAAD）活性增加。这种增加是短暂的，在15至30分钟之间达到峰值，并在大约90分钟时恢复到基线水平。福斯高林处理后AAAD活性的增加不受放线菌酮预处理的影响。动力学研究表明，Vmax明显增加，而L-多巴或磷酸吡哆醛的Km变化很小。我们得出结论，纹状体和中脑的AAAD活性可通过环磷酸腺苷依赖性过程进行调节。
