Simian virus 40 small-t antigen binds two zinc ions.
作者信息
Turk B, Porras A, Mumby M C, Rundell K
机构信息
Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois 60611-3008.
出版信息
J Virol. 1993 Jun;67(6):3671-3. doi: 10.1128/JVI.67.6.3671-3673.1993.
Abstract
Six cysteine residues of the simian virus 40 small-t antigen (small-t) are important for stability of the protein. Stability has been shown to be related to the ability of small-t to bind zinc ions in vitro. Purified small-t expressed either in bacteria or from baculovirus vectors binds two molecules of zinc per molecule of protein. Thus, small-t may resemble GAL4, which contains a Zn(II)2Cys6 binuclear cluster.
摘要
相似文献
1
Simian virus 40 small-t antigen binds two zinc ions.
J Virol. 1993 Jun;67(6):3671-3. doi: 10.1128/JVI.67.6.3671-3673.1993.
2
Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria.
J Virol. 1992 Mar;66(3):1746-51. doi: 10.1128/JVI.66.3.1746-1751.1992.
3
GAL4 transcription factor is not a "zinc finger" but forms a Zn(II)2Cys6 binuclear cluster.
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2077-81. doi: 10.1073/pnas.87.6.2077.
4
The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting.
J Virol. 1991 Jun;65(6):3167-74. doi: 10.1128/JVI.65.6.3167-3174.1991.
5
Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation.
J Virol. 1992 Nov;66(11):6517-26. doi: 10.1128/JVI.66.11.6517-6526.1992.
6
Differential interaction of temperature-sensitive simian virus 40 T antigens with tumor suppressors pRb and p53.
J Virol. 1996 Oct;70(10):7224-7. doi: 10.1128/JVI.70.10.7224-7227.1996.
7
Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2.
J Cell Sci. 2009 Sep 1;122(Pt 17):3190-8. doi: 10.1242/jcs.049627. Epub 2009 Aug 11.
8
Interaction of simian virus 40 small-T antigen produced in bacteria with 56K and 32K proteins of animal cells.
J Virol. 1985 Oct;56(1):325-7. doi: 10.1128/JVI.56.1.325-327.1985.
9
trans-Dominant and non-trans-dominant mutant simian virus 40 large T antigens show distinct responses to ATP.
J Virol. 1997 Oct;71(10):7549-59. doi: 10.1128/JVI.71.10.7549-7559.1997.
10
A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.
J Virol. 1996 Oct;70(10):6902-8. doi: 10.1128/JVI.70.10.6902-6908.1996.
引用本文的文献
1
Iron‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections.
Biochim Biophys Acta Mol Cell Res. 2024 Jun;1871(5):119723. doi: 10.1016/j.bbamcr.2024.119723. Epub 2024 Apr 8.
2
Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer.
Front Microbiol. 2022 Feb 18;13:834368. doi: 10.3389/fmicb.2022.834368. eCollection 2022.
3
The Oncogenic Small Tumor Antigen of Merkel Cell Polyomavirus Is an Iron-Sulfur Cluster Protein That Enhances Viral DNA Replication.
J Virol. 2015 Nov 25;90(3):1544-56. doi: 10.1128/JVI.02121-15. Print 2016 Feb 1.
4
Role of Zn2+ ions in host-virus interactions.
J Virol. 2008 Dec;82(23):11486-94. doi: 10.1128/JVI.01314-08. Epub 2008 Sep 10.
5
SV40 reporter viruses.
J Virol Methods. 2008 Jun;150(1-2):7-13. doi: 10.1016/j.jviromet.2008.02.013. Epub 2008 Apr 9.
6
Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation.
J Cell Physiol. 2008 May;215(2):309-19. doi: 10.1002/jcp.21326.
7
Structural basis of PP2A inhibition by small t antigen.
PLoS Biol. 2007 Aug;5(8):e202. doi: 10.1371/journal.pbio.0050202.
8
Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor.
Mol Cell Biol. 2005 Feb;25(4):1298-308. doi: 10.1128/MCB.25.4.1298-1308.2005.
9
Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.
J Virol. 1999 Jan;73(1):839-42. doi: 10.1128/JVI.73.1.839-842.1999.
10
The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.
Mol Cell Biol. 1997 Aug;17(8):4761-73. doi: 10.1128/MCB.17.8.4761.
本文引用的文献
1
Properties of simian virus 40 small t antigen overproduced in bacteria.
J Virol. 1981 Feb;37(2):683-97. doi: 10.1128/JVI.37.2.683-697.1981.
2
Monoclonal antibodies specific for simian virus 40 tumor antigens.
J Virol. 1981 Sep;39(3):861-9. doi: 10.1128/JVI.39.3.861-869.1981.
3
Interaction of simian virus 40 small-T antigen produced in bacteria with 56K and 32K proteins of animal cells.
J Virol. 1985 Oct;56(1):325-7. doi: 10.1128/JVI.56.1.325-327.1985.
4
Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells.
J Virol. 1988 Aug;62(8):2951-9. doi: 10.1128/JVI.62.8.2951-2959.1988.
5
Zinc release from Xenopus transcription factor IIIA induced by chemical modifications.
Biochemistry. 1989 Dec 12;28(25):9790-5. doi: 10.1021/bi00451a037.
6
Calculation of protein extinction coefficients from amino acid sequence data.
Anal Biochem. 1989 Nov 1;182(2):319-26. doi: 10.1016/0003-2697(89)90602-7.
7
Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.
EMBO J. 1989 Dec 1;8(12):3891-8. doi: 10.1002/j.1460-2075.1989.tb08568.x.
8
The zinc finger region of simian virus 40 large T antigen.
J Virol. 1989 Jan;63(1):94-100. doi: 10.1128/JVI.63.1.94-100.1989.
9
Mutational analysis of simian virus 40 small-t antigen.
J Virol. 1990 Jun;64(6):2895-900. doi: 10.1128/JVI.64.6.2895-2900.1990.
10
Association of protein phosphatase 2A with polyoma virus medium tumor antigen.
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2521-5. doi: 10.1073/pnas.87.7.2521.
Zotero 插件