Du Caju M V, Bleyaert S, Op De Beeck L
Universitair Ziekenhuis Antwerpen.
Acta Clin Belg. 1993;48(1):11-9.
Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls. In this study, growth data of 38 normal girls with a predicted final height beyond 178 cm, are reported. They were treated with ethinyloestradiol in a daily dose of 0.200 mg until the epiphyseal plates were practically fused. In addition, medroxyprogesterone acetate at a dose of 10 mg daily was given for 5 to 12 days every month. The reduction of final height occurred with decreased growth velocity and accelerated epiphyseal closure. The major factor affecting the response to treatment was skeletal age. The lower the skeletal age, the greater the difference between the predicted final height and the final height. This gain was directly related to the growth potential at start of therapy. The best time to start treatment might be the pre-menarche period at a bone age of 12 years. Serious side-effects were not reported, but treatment should be employed only when height prediction is excessive.
大剂量雌激素治疗对体质性身材高大的女孩减少成年身高有效。在本研究中，报告了38名预计最终身高超过178厘米的正常女孩的生长数据。她们接受了每日剂量为0.200毫克的炔雌醇治疗，直至骨骺板几乎融合。此外，每月给予剂量为10毫克的醋酸甲羟孕酮，持续5至12天。最终身高的降低伴随着生长速度的下降和骨骺闭合的加速。影响治疗反应的主要因素是骨龄。骨龄越低，预计最终身高与最终身高之间的差异就越大。这种身高减少直接与治疗开始时的生长潜力有关。开始治疗的最佳时间可能是骨龄为12岁的月经前期。未报告严重副作用，但仅在身高预测过高时才应采用治疗。
