Tarao K, Ohkawa S, Shimizu A, Harada M, Nakamura Y, Okamoto N, Ito Y, Tamai S, Iimori K, Sugimasa Y
Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.
Cancer. 1993 Jun 15;71(12):3859-63. doi: 10.1002/1097-0142(19930615)71:12<3859::aid-cncr2820711211>3.0.co;2-v.
There is a concept that a cancer often maintains some of the traits of the background tissue cells. Thus, the possibility exists that the DNA synthetic activity of the hepatocytes in cirrhotic tissue affects that of hepatocellular carcinoma (HCC) cells.
DNA synthesis activity of hepatocytes from background cirrhotic tissue and HCC cells from cancerous tissue was studied in 30 patients with liver cirrhosis (LC) and HCC who had undergone hepatectomy; the study was done using the bromodeoxyuridine (BrdU)-anti-BrdU in vitro method. The correlation between the BrdU labeling index (LI) of hepatocytes from noncancerous cirrhotic tissue and that of HCC cells was studied. The relationship between both BrdU LI values and the survival after hepatectomy also was studied.
A significant correlation (r = 0.572; P < 0.001) was identified between the BrdU LI for HCC and that for noncancerous cirrhotic tissue. A significant correlation (r = -0.572; P < 0.05) was found between the BrdU LI of HCC cells and the survival after hepatectomy. A significant correlation (r = -0.678; P < 0.01) was observed between the BrdU LI of the noncancerous cirrhotic tissue and the survival.
It was concluded that a significant correlation existed between DNA synthesis of hepatocytes from the background cirrhotic tissue and that of HCC cells and that DNA synthesis activity of hepatocytes from noncancerous cirrhotic tissue and that of HCC cells from cancerous tissue could predict the survival of patients with HCC who had undergone hepatectomy.
有一种观点认为，癌症通常会保留一些背景组织细胞的特征。因此，肝硬化组织中肝细胞的DNA合成活性有可能影响肝细胞癌（HCC）细胞的DNA合成活性。
对30例接受肝切除术的肝硬化（LC）和HCC患者，采用体外溴脱氧尿苷（BrdU）-抗BrdU法，研究背景肝硬化组织中肝细胞和癌组织中HCC细胞的DNA合成活性。研究了非癌性肝硬化组织中肝细胞的BrdU标记指数（LI）与HCC细胞的BrdU标记指数之间的相关性。还研究了两个BrdU LI值与肝切除术后生存率之间的关系。
HCC的BrdU LI与非癌性肝硬化组织的BrdU LI之间存在显著相关性（r = 0.572；P < 0.001）。HCC细胞的BrdU LI与肝切除术后生存率之间存在显著相关性（r = -0.572；P < 0.05）。非癌性肝硬化组织的BrdU LI与生存率之间存在显著相关性（r = -0.678；P < 0.01）。
得出结论，背景肝硬化组织中肝细胞的DNA合成与HCC细胞的DNA合成之间存在显著相关性，非癌性肝硬化组织中肝细胞的DNA合成活性和癌组织中HCC细胞的DNA合成活性可预测接受肝切除术的HCC患者的生存率。
