肝细胞癌中DNA合成存在性别差异的证据。
Evidence of sex difference in DNA synthesis in hepatocellular carcinoma.
作者信息
Tarao K, Shimizu A, Harada M, Ono T, Kuni Y, Ohkawa S, Ito Y, Tamai S, Iimori K, Sugimasa Y
机构信息
Department of Gastroenterology, Kanagawa Cancer Center, Yokohama.
出版信息
Jpn J Cancer Res. 1991 Aug;82(8):922-6. doi: 10.1111/j.1349-7006.1991.tb01922.x.
To clarify sex differences in DNA synthesis in hepatocellular carcinoma (HCC), bromodeoxyuridine labeling indices (BrdU LI) of HCC cells included in tumor biopsy specimens from 12 consecutive male patients and from 5 consecutive female patients all with liver cirrhosis and HCC were examined using an in vitro labeling technique. The mean BrdU LI +/- SE of HCC from male patients (7.7 +/- 0.8%) was significantly (P less than 0.05) higher than that from female patients (4.4 +/- 1.0%). While 7 of the 12 male HCC patients belonged to the high DNA synthesis group (BrdU LI greater than or equal to 7.0%), none of the 5 female HCC patients showed high DNA synthesis (P less than 0.05). We conclude that DNA synthesis in HCC was higher in males than in females.
为阐明肝细胞癌（HCC）中DNA合成的性别差异，采用体外标记技术检测了12例连续男性患者和5例连续女性患者的肿瘤活检标本中HCC细胞的溴脱氧尿苷标记指数（BrdU LI），所有患者均患有肝硬化和HCC。男性患者HCC的平均BrdU LI±SE（7.7±0.8%）显著高于女性患者（4.4±1.0%）（P<0.05）。12例男性HCC患者中有7例属于高DNA合成组（BrdU LI≥7.0%），而5例女性HCC患者均未表现出高DNA合成（P<0.05）。我们得出结论，HCC中的DNA合成男性高于女性。
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