Pfaller M, Barry A, Fuchs P, Gerlach E, Hardy D, McLaughlin J
Department of Pathology, Oregon Health Sciences University, Portland 97201.
Eur J Clin Microbiol Infect Dis. 1993 Mar;12(3):200-5. doi: 10.1007/BF01967112.
Three beta-lactamase inhibitors were combined with ampicillin in a fixed 2:1 ratio. The activity of ampicillin was enhanced by tazobactam and by clavulanic acid, and to a lesser extent by sulbactam when tested against fresh clinical isolates of Enterobacteriaceae. At a concentration of 8 micrograms/ml, ampicillin alone inhibited 49.6% of 2,434 consecutive isolates of enteric bacilli compared to 81% inhibited by ampicillin combined with tazobactam or clavulanic acid and 69.3% inhibited by the sulbactam/ampicillin combination. A four-fold or greater reduction in ampicillin MICs was observed in comparable numbers of isolates with all three combinations, but the most marked effects were seen with strains that were highly resistant to ampicillin.
三种β-内酰胺酶抑制剂与氨苄西林以固定的2:1比例联合使用。在针对肠杆菌科新鲜临床分离株进行测试时，他唑巴坦和克拉维酸增强了氨苄西林的活性，舒巴坦增强的程度较小。在浓度为8微克/毫升时，单独的氨苄西林抑制了2434株连续肠道杆菌分离株中的49.6%，相比之下，氨苄西林与他唑巴坦或克拉维酸联合使用时抑制率为81%，舒巴坦/氨苄西林联合使用时抑制率为69.3%。在所有三种联合用药的相当数量的分离株中，氨苄西林的最低抑菌浓度（MIC）均降低了四倍或更多，但对氨苄西林高度耐药的菌株表现出最显著的效果。
