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Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice.在人神经母细胞瘤细胞中筛选出的脊髓灰质炎病毒突变体衣壳中的替换，赋予了马奥尼1型毒株在小鼠中具有神经毒力的表型。
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A single amino acid substitution in the capsid protein VP1 of coxsackievirus B3 (CVB3) alters plaque phenotype in Vero cells but not cardiovirulence in a mouse model.柯萨奇病毒B3（CVB3）衣壳蛋白VP1中的单个氨基酸取代会改变其在Vero细胞中的蚀斑表型，但不会改变其在小鼠模型中的心脏毒力。
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Observations on encephalomyelitis of mice (DA strain).对小鼠（DA品系）脑脊髓炎的观察
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Precise missense and silent point mutations are fixed in the genomes of poliovirus mutants from persistently infected cells.精确的错义突变和沉默点突变在持续感染细胞来源的脊髓灰质炎病毒突变体基因组中固定下来。
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Persistent infection of human fibroblasts by hepatitis A virus.甲型肝炎病毒对人成纤维细胞的持续感染。
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Primary structure, gene organization and polypeptide expression of poliovirus RNA.脊髓灰质炎病毒RNA的一级结构、基因组织及多肽表达
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An infectious cDNA clone of the poliovirus Sabin strain could be used as a stable repository and inoculum for the oral polio live vaccine.脊髓灰质炎病毒萨宾株的感染性 cDNA 克隆可作为口服脊髓灰质炎减毒活疫苗的稳定储存库和接种物。
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Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I.脊髓灰质炎病毒的宿主范围由中和抗原位点I中的一段短氨基酸序列决定。
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Persistent poliovirus infection of human neuroblastoma cells.人类神经母细胞瘤细胞的持续性脊髓灰质炎病毒感染
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Anti-thymocyte serum delays clearance of poliovirus from the mouse central nervous system.
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Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice.在1型衣壳上构建2型脊髓灰质炎病毒抗原位点会产生一种对小鼠具有神经毒性的嵌合病毒。
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鉴定脊髓灰质炎病毒基因组中与HEp-2细胞持续感染有关的区域。

Identification of a region of the poliovirus genome involved in persistent infection of HEp-2 cells.

作者信息

Calvez V, Pelletier I, Borzakian S, Colbère-Garapin F

机构信息

Unité de Virologie Médicale, Institute Pasteur, Paris, France.

出版信息

J Virol. 1993 Jul;67(7):4432-5. doi: 10.1128/JVI.67.7.4432-4435.1993.

DOI:10.1128/JVI.67.7.4432-4435.1993
PMID:8389941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC237820/
Abstract

Poliovirus mutants were selected during the persistent infection of human neuroblastoma cells. These viruses could establish secondary persistent infections in HEp-2 nonneural cells. We report the identification of a region of the genome of a persistent virus (S11) that was sufficient to confer to a recombinant virus the phenotype that causes persistent infection in HEp-2 cells. This region, between nucleotides 1148 and 3481, contained 11 missense mutations mapping exclusively in the genes of capsid proteins VP1 and VP2. Because recombinant viruses carrying only one of these two mutated genes were not able to cause persistent infection, it seems very probable that two or more mutations in these genes are required for expression of the phenotype that causes persistent infection.

摘要

脊髓灰质炎病毒突变体是在人神经母细胞瘤细胞的持续感染过程中筛选出来的。这些病毒能够在HEp-2非神经细胞中建立继发性持续感染。我们报告了一种持续病毒（S11）基因组区域的鉴定结果，该区域足以赋予重组病毒在HEp-2细胞中引起持续感染的表型。这个位于核苷酸1148至3481之间的区域包含11个错义突变，这些突变仅定位在衣壳蛋白VP1和VP2的基因中。由于仅携带这两个突变基因之一的重组病毒无法引起持续感染，因此很可能这些基因中的两个或更多个突变是表达引起持续感染的表型所必需的。