致癌物苯并[a]芘的高致突变性7,8-二醇9,10-环氧化物的合成与反应 - Suppr

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Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene.

作者信息

Yagi H, Thakker D R, Hernandez O, Koreeda M, Jerina D M

出版信息

J Am Chem Soc. 1977 Mar 2;99(5):1604-11. doi: 10.1021/ja00447a053.

DOI:10.1021/ja00447a053

PMID:839009

Abstract

摘要

相似文献

Synthesis and reactions of the highly mutagenic 7,8-diol 9,10-epoxides of the carcinogen benzo[a]pyrene.致癌物苯并[a]芘的高致突变性7,8-二醇9,10-环氧化物的合成与反应

J Am Chem Soc. 1977 Mar 2;99(5):1604-11. doi: 10.1021/ja00447a053.

Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.苯并(a)芘苯环环氧化物的致突变性和细胞毒性。

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Absolute sterochemistry of the highly mutagenic 7,8-diol 9,10-epoxides derived from the potent carcinogen trans-7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene.源自强效致癌物反式-7,8-二羟基-7,8-二氢苯并[a]芘的高致突变性7,8-二醇9,10-环氧化物的绝对立体化学。

J Am Chem Soc. 1977 Mar 30;99(7):2358-9. doi: 10.1021/ja00449a066.

Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells.苯并[a]芘和苯并[a]蒽的异构二醇环氧化物在鼠伤寒沙门氏菌TA98和TA100以及V79中国仓鼠细胞中的诱变性。

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Letter: Synthesis of (+/-)-7 beta,8alpha-dihydroxy-9 beta,10beta-epoxy-7,8,-9,10-tetrahydrobenzo(a)pyrene, a potential metabolite of the carcinogen benzo(a)pyrene with stereochemistry related to the antileukemic triptolides.信函：（±）-7β，8α-二羟基-9β，10β-环氧-7,8,-9,10-四氢苯并（a）芘的合成，苯并（a）芘的一种潜在代谢产物，其立体化学与抗白血病雷公藤内酯醇相关。

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Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides.非对映体苯并[a]芘7,8-二醇-9,10-环氧化物光学对映体的诱变性差异。

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Mutagenicity of the bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene.二苯并（a，h）芘和二苯并（a，i）芘的湾区二醇环氧化物及其他苯环衍生物的诱变性。

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Relationships of quantum mechanical calculations, relative mutagenicity of benzo[a]anthracene diol epoxides, and "bay region" concept of aromatic hydrocarbon carcinogenicity.量子力学计算、苯并[a]蒽二醇环氧化物的相对诱变性与芳烃致癌性“湾区”概念之间的关系。

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