Abdool Karim S S, Tait D R
South African Medical Research Council (Natal), Durban.
S Afr Med J. 1993 Mar;83(3):191-3.
This study was undertaken to estimate the prevalence of hepatitis C virus (HCV) infection in urban and rural blacks in Natal/KwaZulu. Sera from representative community-based samples comprising 176 urban and 441 rural black adults were tested for the presence of anti-HCV. The prevalence of HCV infection was 1.7% (95% confidence interval 0-3.6%) among urban and 0.9% (95% confidence interval 0.1-1.7%) among rural blacks. Four (0.9%) of the 466 subjects with evidence of current or past hepatitis B virus (HBV) infection and 3 (2%) of the 151 with no evidence of HBV infection were anti-HCV-positive. The prevalence of HCV infection was low in contrast to the high prevalence of HBV infection among urban and rural blacks in Natal/KwaZulu. This suggests that HCV does not have the same main routes of transmission as HBV in this region. Larger scale studies are needed to explore this hypothesis.
本研究旨在估计纳塔尔/夸祖鲁城乡黑人中丙型肝炎病毒（HCV）感染的流行率。对来自具有代表性的社区样本（包括176名城市黑人成年人和441名农村黑人成年人）的血清进行抗HCV检测。城市黑人中HCV感染的流行率为1.7%（95%置信区间0 - 3.6%），农村黑人中为0.9%（95%置信区间0.1 - 1.7%）。466名有当前或既往乙型肝炎病毒（HBV）感染证据的受试者中有4名（0.9%）抗HCV呈阳性，151名无HBV感染证据的受试者中有3名（2%）抗HCV呈阳性。与纳塔尔/夸祖鲁城乡黑人中HBV感染的高流行率相比，HCV感染的流行率较低。这表明在该地区HCV与HBV的主要传播途径不同。需要开展更大规模的研究来探究这一假设。
