Ndumbe P M, Skalsky J
Virus Immunology Unit, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon.
Scand J Infect Dis. 1993;25(6):689-92. doi: 10.3109/00365549309008564.
We tested serum samples collected in an urban setting (Yaounde) and in a rural area (Manyemen) for the presence of antibody to hepatitis C virus (HCV) (anti-HCV). Screening was done by second-generation ELISA and confirmation with second-generation RIBA. In Yaounde, anti-HCV was found in 12.5% of patients with febrile jaundice (95% CL 3.8-21.2), 5.5% of pregnant women (95% CL 3.3-7.3), 0% of children below 4 years of age, 31% of sickle cell patients (95% CL 20.2-41.8%), 1.6% of medical students (95% CL 0-4.7%) and 15.4% of prostitutes (95% CL 8.5-22.3). Only HBsAg-negative sera were tested for anti-HCV, except sera originating from subjects with febrile jaundice. In Manyemen, anti-HCV was detected in 6.4% of blood donors, 6.0% of pregnant women, 5.3% of HIV-positive subjects, 7.3% of RPR-positive and 3.9% of RPR-negative subjects. There was an increase in antibody prevalence with age. We conclude that HCV infection is common in Cameroon and that it is transmitted mainly by blood transfusion and probably by sexual activity.
我们检测了在城市地区（雅温得）和农村地区（曼耶门）采集的血清样本，以检测丙型肝炎病毒（HCV）抗体（抗-HCV）的存在情况。筛查采用第二代酶联免疫吸附测定（ELISA）进行，并通过第二代重组免疫印迹法（RIBA）进行确认。在雅温得，发热性黄疸患者中12.5%检测到抗-HCV（95%可信区间3.8 - 21.2），孕妇中5.5%（95%可信区间3.3 - 7.3），4岁以下儿童中0%，镰状细胞病患者中31%（95%可信区间20.2 - 41.8%），医学生中1.6%（95%可信区间0 - 4.7%），妓女中15.4%（95%可信区间8.5 - 22.3）。除发热性黄疸患者的血清外，仅对乙肝表面抗原（HBsAg）阴性的血清检测抗-HCV。在曼耶门，6.4%的献血者、6.0%的孕妇、5.3%的艾滋病毒阳性者、7.3%的快速血浆反应素环状卡片试验（RPR）阳性者和3.9%的RPR阴性者检测到抗-HCV。抗体流行率随年龄增加。我们得出结论，HCV感染在喀麦隆很常见，主要通过输血传播，也可能通过性活动传播。
