Kovalic J J, Simpson J R
Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, Missouri.
J Otolaryngol. 1993 Apr;22(2):118-20.
Thirteen patients with primary carcinoma of the hard palate were seen over an 18-year period at the Mallinckrodt Institute of Radiology. Nine patients had adenoid cystic carcinoma, three had squamous cell carcinoma, and one patient had mucoepidermoid carcinoma. The median tumor size was 3 cm3. The patients were clinically staged: T = 1, T2 = 5, T3 = 3, T4 = 4. All were N0M0. Ten patients underwent excision and postoperative irradiation. The remaining three patients were treated definitively with radiotherapy. The 10-year disease-free survival is 77% with an actuarial local control rate of 92%. Patients with negative surgical margins had an improved local control and disease-free survival. Duration of radiation therapy, total tumor dose or histology had no impact on outcome. We conclude that combined surgery and irradiation gives good 10-year local control and disease-free survival rates in patients with this disease.
在18年的时间里，马林克罗特放射研究所共接诊了13例原发性硬腭癌患者。其中9例为腺样囊性癌，3例为鳞状细胞癌，1例为黏液表皮样癌。肿瘤中位大小为3立方厘米。患者的临床分期为：T1 = 1例，T2 = 5例，T3 = 3例，T4 = 4例。所有患者均为N0M0。10例患者接受了手术切除及术后放疗。其余3例患者接受了单纯放疗。10年无病生存率为77%，精算局部控制率为92%。手术切缘阴性的患者局部控制和无病生存率有所提高。放疗持续时间、总肿瘤剂量或组织学类型对预后均无影响。我们得出结论，对于本病患者，手术联合放疗可带来良好的10年局部控制率和无病生存率。
