Brambilla F, Ferrari E, Panerai A, Manfredi B, Petraglia F, Catalano M, Sacerdote P
Psychoneuroendocrine Center, Psychiatric Hospital Pini, Milan, Italy.
Neuropsychobiology. 1993;27(1):9-16. doi: 10.1159/000118947.
Immunological and neuroendocrine parameters were examined in 11 women with anorexia nervosa, 6 restricted and 5 bulimic-anorectics, 17-43 years old with 2-15 years duration of the disease, and in 11 age- and sex-matched psychophysically healthy controls. The T lymphocyte proliferative response to phytohemagglutinin (PHA), plasma adrenocorticotropic hormone (ACTH), cortisol and beta-endorphin (beta-EP) levels was examined in basal conditions and after corticotropin-releasing hormone (CRH) stimulation. Cortisol inhibition by dexamethasone (DST), and basal growth hormone (GH) and prolactin (PRL) levels were also examined. The immune study did not reveal significant differences between patients and controls. ACTH and cortisol basal levels were significantly higher in anorectics, while beta-EP, GH and PRL concentrations did not differ in the two groups. ACTH, beta-EP and cortisol responses to CRH were blunted in anorectics and the DST impaired in 55% of the patients. No correlations were observed between neuroendocrine impairments and the T lymphocyte response to PHA, or between the immunological neuroendocrine parameters and the body mass index of either patients or controls.
对11名神经性厌食症女性患者进行了免疫和神经内分泌参数检测，其中6名是节食型，5名是贪食 - 厌食型，年龄在17 - 43岁之间，病程为2 - 15年，并与11名年龄和性别匹配的身心健康对照者进行了比较。在基础状态和促肾上腺皮质激素释放激素（CRH）刺激后，检测了对植物血凝素（PHA）的T淋巴细胞增殖反应、血浆促肾上腺皮质激素（ACTH）、皮质醇和β - 内啡肽（β - EP）水平。还检测了地塞米松（DST）对皮质醇的抑制作用以及基础生长激素（GH）和催乳素（PRL）水平。免疫研究未发现患者与对照者之间有显著差异。厌食症患者的ACTH和皮质醇基础水平显著更高，而两组的β - EP、GH和PRL浓度无差异。厌食症患者对CRH的ACTH、β - EP和皮质醇反应减弱，55%的患者DST功能受损。未观察到神经内分泌损伤与T淋巴细胞对PHA的反应之间存在相关性，也未观察到免疫神经内分泌参数与患者或对照者的体重指数之间存在相关性。
