Brambilla F, Bellodi L, Perna G, Battaglia M, Sciuto G, Diaferia G, Petraglia F, Panerai A, Sacerdote P
Ospedale Psichiatrico Pini, Istituto Scientifico S. Raffaele, Milano, Italia.
Neuropsychobiology. 1992;26(1-2):12-22. doi: 10.1159/000118890.
Immunological, neuroendocrine and psychological parameters were examined in 14 psychophysically healthy subjects and in 17 panic disorder patients before and after a 30-day course of alprazolam therapy. T lymphocyte proliferation in response to the mitogen phytohemagglutinin, lymphocyte beta-endorphin (beta-EP) concentrations, plasma ACTH, cortisol and beta-EP levels were examined in basal conditions and after corticotropin-releasing hormone (CRH) stimulation. Cortisol inhibition by dexamethasone (DST) and basal growth hormone (GH) and prolactin levels were also examined. Depression, state or trait anxiety, anticipatory anxiety, agoraphobia, simple and social phobias, severity and frequency of panic attacks were monitored by rating scales. The immune study did not reveal any significant difference between patients and controls, or any effect of alprazolam therapy. The hormonal data for the two groups were similar, except for higher than normal basal ACTH and GH plasma levels, lower than normal ratios between the ACTH and cortisol responses to CRH, and blunted DST in some patients. All the impairments improved after alprazolam therapy, in parallel with decreases in anxiety and in severity and frequency of panic attacks.
在14名身心健康的受试者以及17名惊恐障碍患者中，于阿普唑仑治疗30天疗程前后对免疫、神经内分泌和心理参数进行了检测。在基础状态以及促肾上腺皮质激素释放激素（CRH）刺激后，检测了对有丝分裂原植物血凝素产生反应的T淋巴细胞增殖、淋巴细胞β-内啡肽（β-EP）浓度、血浆促肾上腺皮质激素（ACTH）、皮质醇和β-EP水平。还检测了地塞米松对皮质醇的抑制作用（DST）以及基础生长激素（GH）和催乳素水平。通过评定量表监测抑郁、状态或特质焦虑、预期焦虑、广场恐惧症、单纯恐惧症和社交恐惧症、惊恐发作的严重程度和频率。免疫研究未发现患者与对照组之间有任何显著差异，也未发现阿普唑仑治疗有任何效果。两组的激素数据相似，但部分患者的基础ACTH和GH血浆水平高于正常，ACTH与皮质醇对CRH反应的比值低于正常，且DST反应减弱。阿普唑仑治疗后，所有这些损害均有所改善，同时焦虑以及惊恐发作的严重程度和频率也有所降低。
