Epstein J B, Sherlock C H, Wolber R A
Medical/Dental Staff, British Columbia Cancer Agency, Vancouver, Canada.
Oral Surg Oral Med Oral Pathol. 1993 Jun;75(6):690-5. doi: 10.1016/0030-4220(93)90424-3.
Hairy leukoplakia in 10 patients after bone marrow transplantation was identified clinically and assessed histologically. In situ hybridization for Epstein-Barr virus and human papilloma virus confirmed Epstein-Barr virus in hairy leukoplakia in two cases, and human papillomavirus in three cases. All cases with clinical follow-up resolved without treatment. These findings suggest that severe immunosuppression after a bone marrow transplantation may result in the development of hairy leukoplakia, and that as the immunosuppression resolves after the transplant the lesions also resolve.
对10例骨髓移植后出现毛发状白斑的患者进行了临床诊断，并进行了组织学评估。针对爱泼斯坦-巴尔病毒和人乳头瘤病毒的原位杂交检测证实，2例毛发状白斑患者感染了爱泼斯坦-巴尔病毒，3例感染了人乳头瘤病毒。所有接受临床随访的病例未经治疗均自行缓解。这些发现表明，骨髓移植后的严重免疫抑制可能导致毛发状白斑的发生，并且随着移植后免疫抑制的缓解，病变也会消退。
