Itin P, Rufli T, Rüdlinger R, Cathomas G, Huser B, Podvinec M, Gudat F
Department of Dermatology, University of Basel, Switzerland.
Dermatologica. 1988;177(2):126-8. doi: 10.1159/000248529.
We report the case of a 58-year-old renal transplant patient who developed oral hairy leukoplakia. Examination for HIV-1 and HIV-2 infection was negative. Biopsy of the lateral tongue showed ballooned prickle cells and electron microscopy revealed herpes-type viruses. In situ hybridization and examinations with the Southern blot technique yielded Epstein-Barr virus. Serology for Epstein-Barr virus was reactive. Immunological investigation of the patient showed a marked decrease of T-helper and T-suppressor cells as the result of immunosuppressive regimen. Oral hairy leukoplakia may be a marker for severe immunosuppression but is not necessarily associated with HIV infection.
我们报告了一例58岁肾移植患者发生口腔毛状白斑的病例。对其进行的HIV-1和HIV-2感染检测均为阴性。舌外侧活检显示棘细胞气球样变，电子显微镜检查发现疱疹型病毒。原位杂交和Southern印迹技术检测均检出EB病毒。EB病毒血清学反应呈阳性。对该患者的免疫学调查显示，由于免疫抑制方案，辅助性T细胞和抑制性T细胞显著减少。口腔毛状白斑可能是严重免疫抑制的一个标志，但不一定与HIV感染相关。
