蛙皮素受体拮抗剂可区分大鼠脑中的受体亚型。

Bombesin receptor antagonists differentiate receptor subtypes in rat brain.

作者信息

Ladenheim E E, Jensen R T, Mantey S A, Taylor J E, Coy D H, Moran T H

机构信息

Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205.

出版信息

Eur J Pharmacol. 1993 Apr 22;235(1):121-5. doi: 10.1016/0014-2999(93)90830-b.

DOI:10.1016/0014-2999(93)90830-b

PMID:8390937

Abstract

Previous studies have shown that various bombesin receptor antagonists can distinguish between bombesin receptor subtypes in peripheral tissues. To determine whether these antagonists would be useful in differentiating bombesin receptor subtypes in the rat central nervous system, we used in vitro receptor autoradiography to examine the binding affinities of several bombesin receptor antagonists for two brain regions we had characterized as possessing distinct bombesin receptor subtypes. Our results demonstrate that, consistent with peripheral bombesin receptors, bombesin receptor subtypes in the rat brain can be differentiated by various bombesin receptor antagonists.

摘要

先前的研究表明，各种蛙皮素受体拮抗剂能够区分外周组织中的蛙皮素受体亚型。为了确定这些拮抗剂是否有助于区分大鼠中枢神经系统中的蛙皮素受体亚型，我们利用体外受体放射自显影技术，检测了几种蛙皮素受体拮抗剂对我们已确定具有不同蛙皮素受体亚型的两个脑区的结合亲和力。我们的结果表明，与外周蛙皮素受体一致，大鼠脑中的蛙皮素受体亚型可通过各种蛙皮素受体拮抗剂加以区分。