用干扰素α-2b长期治疗慢性丙型肝炎：在一项针对8名血友病患者的初步研究中丙型肝炎病毒核糖核酸的消失情况
Long term treatment of chronic hepatitis C with interferon alfa-2b: disappearance of HCV-RNA in a pilot study of eight haemophilia patients.
作者信息
Bresters D, Mauser-Bunschoten E P, Cuypers H T, Han J H, Jansen P L, Chamuleau R A, Houghton M, Reesink H W
机构信息
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
出版信息
Gut. 1993;34(2 Suppl):S124-5. doi: 10.1136/gut.34.2_suppl.s124.
This pilot study was designed to establish the effect of long term alpha interferon treatment in haemophilia patients with chronic hepatitis C. Overall, three of eight (37.5%) patients showed a complete response, three of eight (37.5%) a transient response, and two of eight (25.0%) no response. HCV-RNA detection by polymerase chain reaction was more sensitive in detecting relapse than alanine amino-transferase (ALT) activity measurement, suggesting that current interferon schedules based on the ALT response should be re-evaluated critically.
本初步研究旨在确定长期使用α干扰素治疗丙型肝炎血友病患者的效果。总体而言，8名患者中有3名（37.5%）显示完全缓解，8名中有3名（37.5%）短暂缓解，8名中有2名（25.0%）无缓解。通过聚合酶链反应检测HCV-RNA在检测复发方面比测量丙氨酸氨基转移酶（ALT）活性更敏感，这表明基于ALT反应的当前干扰素治疗方案应受到严格重新评估。
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