Hirai T, Ohishi H, Guo Q, Sakaguchi S, Imai T, Ohmichi R, Sakaguchi H, Nagano N, Yoshioka T, Matsuo N
Department of oncoradiology, Nara Medical University.
Nihon Igaku Hoshasen Gakkai Zasshi. 1993 May 25;53(5):511-9.
The distribution of blood flow was determined from the distribution of CO2 by US performed during the infusion of CO2 microbubbles via an implantable port (IP-CO2US) in intraarterial chemotherapy for hepatic tumor, and the usefulness of this method in determining tumor vascularity and evaluating the effects of therapy was investigated. A total of 16 patients, 12 of whom had metastatic liver tumor, two hepatocellular carcinoma, one gall bladder carcinoma, and one cholangiocellular carcinoma were studied. The enhanced areas in the liver in 16 patients in whom IP-CO2US was performed a total of 24 times were consistent in all cases with the enhanced areas demonstrated by IP-RI angiography performed a total of 10 times within 10 days, and were also consistent with one exception with the enhanced areas demonstrated by IP-CTA performed 14 times. The tumor detection rate was markedly higher with IP-CO2US than with plain US or IP-DSA, and was similar to that of IP-CTA. Evaluation of the vascularity of individual nodules by IP-CO2US surpassed that by IP-DSA, and was similar to that of IP-CTA. It was demonstrated that blood flow distribution (intrahepatic drug distribution) can be equally well grasped with IP-CO2US, which is a simple and convenient method, as with IP-RI angiography. It was also suggested that IP-CO2US is useful in the evaluation of tumor vascularity and the effect of therapy.
在肝肿瘤动脉内化疗过程中，通过植入式端口（IP-CO2US）注入二氧化碳微泡，利用超声根据二氧化碳分布确定血流分布，并研究该方法在确定肿瘤血管和评估治疗效果方面的实用性。共研究了16例患者，其中12例有肝转移瘤，2例肝细胞癌，1例胆囊癌和1例胆管细胞癌。对16例患者共进行了24次IP-CO2US检查，其肝脏内增强区域在所有病例中均与10天内共进行10次的IP-RI血管造影所显示的增强区域一致，除1例例外，也与14次IP-CTA所显示的增强区域一致。IP-CO2US的肿瘤检出率明显高于普通超声或IP-DSA，与IP-CTA相似。IP-CO2US对单个结节血管的评估超过IP-DSA，与IP-CTA相似。结果表明，IP-CO2US作为一种简单方便的方法，与IP-RI血管造影一样，能够很好地掌握血流分布（肝内药物分布）。还提示IP-CO2US在评估肿瘤血管和治疗效果方面是有用的。
