Devuyst O, Lefebvre C, Geubel A, Coche E
Dépt. de Médecine Interne, Cliniques Universitaires St. Luc, Faculté de Médecine de l'U.C.L., Bruxelles.
Acta Clin Belg. 1993;48(2):109-14. doi: 10.1080/17843286.1993.11718294.
We report a case of acute cholestatic hepatitis associated with rash and hypereosinophilia, in which the absence of transfusion, intercurrent viral infection, alcohol consumption or other hepatotoxic drugs are suggestive of ranitidine-induced hepatotoxicity. The pathogenesis of the disorder is unknown, but the lack of a dose-effect relationship, the rarity and unpredictability of the reaction, as well as the clinical signs suggest that hypersensitivity is involved. Physicians should be aware of this rare and idiosyncratic side-effect of ranitidine.
我们报告了一例伴有皮疹和嗜酸性粒细胞增多的急性胆汁淤积性肝炎病例，其中不存在输血、并发病毒感染、饮酒或使用其他肝毒性药物的情况，提示为雷尼替丁所致肝毒性。该疾病的发病机制尚不清楚，但缺乏剂量效应关系、反应的罕见性和不可预测性以及临床体征提示涉及超敏反应。医生应了解雷尼替丁这种罕见且特异的副作用。
