Penn R D, Kurtz D
J Neurosurg. 1977 Mar;46(3):282-9. doi: 10.3171/jns.1977.46.3.0282.
The authors conducted quantitative analysis of computerized tomography (CT) scans to measure tumor size, cerebral edema, and regional blood volume in man. Mass lesions without edema caused a local reduction in blood volume. Cerebral edema also reduced blood volume in proportion to its severity. Consideration of the electrolyte changes and water shifts in white-matter edema suggested that the decrease in absorption coefficient seen in CT scans was due to the increase in water content. Thus, in cerebral edema separation of blood vessels as well as increased interstitial pressure decrease blood volume, and the regional differences in turn reflect pressure gradients within the brain.
作者对计算机断层扫描（CT）进行了定量分析，以测量人体肿瘤大小、脑水肿和局部血容量。无水肿的肿块病变导致局部血容量减少。脑水肿也会根据其严重程度相应地降低血容量。对白质水肿中电解质变化和水转移的研究表明，CT扫描中吸收系数的降低是由于含水量增加所致。因此，在脑水肿中，血管分离以及间质压力增加会降低血容量，而区域差异反过来反映了脑内的压力梯度。
