Dvoretskiĭ A I, Kulikova I A
Radiobiologiia. 1993 May-Jun;33(3):402-7.
Whole-body X irradiation with doses of 0.155 and 0.310 C/kg was shown to modify in different ways the activating effects of noradrenaline and serotonin, as well as a biphase effect of dopamine (5.10(-8)--1.5.10(-3) M) on Na,K-pump of neuronal membranes. The resulting effect was a function of a combination of radiation doses and neurotransmitter concentrations and thus showed different modes of interaction between neurotransmitter and ion-transport systems of brain cells in radiation sickness. The authors discuss possible molecular mechanisms of radiation modification of the functional interaction between the neurotransmitter and the active ion-transport systems in nerve cells.
全身照射剂量为0.155和0.310库仑/千克时，已表明会以不同方式改变去甲肾上腺素和血清素的激活作用，以及多巴胺（5×10⁻⁸ - 1.5×10⁻³摩尔）对神经元膜钠钾泵的双相效应。所产生的效应是辐射剂量和神经递质浓度组合的函数，因此显示出辐射病中神经递质与脑细胞离子转运系统之间不同的相互作用模式。作者讨论了辐射对神经细胞中神经递质与活性离子转运系统之间功能相互作用进行修饰的可能分子机制。
