Yasuno K, Matsunaga W, Ishihara T
Division of Plastic and Reconstructive Surgery, Kumamoto Municipal Hospital.
Gan To Kagaku Ryoho. 1993 Jul;20(9):1253-6.
For metastatic lung region, a 82-year-old woman with malignant fibrous histiocytoma was successfully treated with combination chemotherapy of Carboplatin and Etoposide. First, the tumor appeared on her right thigh, and we operated on August 1991. However, at the same time, a metastatic lung region was also noticed. Over a year, it worsened. We gave her 350 mg Carboplatin once a week and 100 mg Etoposide 3 times a week. After 3 weeks' treatment, we stopped treatment because of sudden granulocytopenia and thrombocytopenia. But to our surprise, the metastatic lung region almost disappeared 2 months after therapy. Considering the difficulty of medical treatment for malignant fibrous histiocytoma, this case suggests that combination chemotherapy of Carboplatin and Etoposide is valuable. However, due care must be taken for side effects such as granulocytopenia and thrombocytopenia.
对于一名患有恶性纤维组织细胞瘤的82岁女性的转移性肺部病灶，采用卡铂和依托泊苷联合化疗成功进行了治疗。起初，肿瘤出现在她的右大腿，于1991年8月进行了手术。然而，与此同时，也发现了肺部转移灶。一年多来，病情恶化。我们给予她每周一次350毫克卡铂和每周三次100毫克依托泊苷。治疗3周后，由于突然出现粒细胞减少和血小板减少而停止治疗。但令我们惊讶的是，治疗2个月后转移性肺部病灶几乎消失。考虑到恶性纤维组织细胞瘤的治疗难度，该病例表明卡铂和依托泊苷联合化疗是有价值的。然而，必须密切关注粒细胞减少和血小板减少等副作用。
