Morikawa T, Takeuchi K, Furuie H, Kimura M, Fukumura M, Kakuta Y, Tashiro Y, Konishi T, Hayashi Y
Department of Respiratory Medicine, Yokohama Rosai Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Sep;33(9):993-8.
A 47-year-old woman was admitted to our hospital with a mass shadow in the upper lobe of the right lung. Undifferentiated carcinoma was diagnosed after transbronchial biopsy. Combination chemotherapy consisting of cisplatin and etoposide was given. After two cycles of chemotherapy, partial response was obtained, and surgery was done because there was no evidence of lymph node metastasis or distant metastasis. After successful surgery, malignant fibrous histiocytoma was diagnosed because histological examination revealed the typical storiform pattern and most tumor cells showed positive cytoplasmic staining for alpha 1-antitrypsin, alpha 1-antichymotrypsin, and CD68. No evidence of another primary lesion was found, so this tumor was thought to be a pulmonary malignant fibrous histiocytoma. Cisplatin and etoposide have synergistic effect in vivo, and this combination is widely used as a standard regimen for small cell lung cancer and other malignancies. It might also be effective against pulmonary malignant fibrous histiocytoma.
一名47岁女性因右肺上叶出现肿块阴影入院。经支气管活检后诊断为未分化癌。给予顺铂和依托泊苷联合化疗。两个化疗周期后获得部分缓解，因无淋巴结转移或远处转移证据而行手术。手术成功后，经组织学检查发现典型的席纹状结构，且大多数肿瘤细胞α1-抗胰蛋白酶、α1-抗糜蛋白酶和CD68的细胞质染色呈阳性，诊断为恶性纤维组织细胞瘤。未发现其他原发性病变证据，因此该肿瘤被认为是肺部恶性纤维组织细胞瘤。顺铂和依托泊苷在体内有协同作用，这种联合方案被广泛用作小细胞肺癌和其他恶性肿瘤的标准治疗方案。它可能对肺部恶性纤维组织细胞瘤也有效。
