Kaaden O R
Institut für Medizinische Mikrobiologie, Infektions- und Seuchenmedizin, Tierärztliche Fakultät, Ludwig-Maximilians-Universität München.
Zentralbl Hyg Umweltmed. 1993 Feb;194(1-2):109-17.
The establishment of persistent virus infections can be regarded as evolutionary mechanisms to protect viruses against the host immune reactions and to enable the perpetuation of virus infections. In principle, persistent or latent virus infections are known among most species of all virus families. Among the different strategies which envolved during virus infections, three mechanisms leading to persistent or latent infections are chosen and discussed in greater detail in this review: Masking of critical epitopes and apparent lack of neutralizing antibody by Aleutian Disease Parvovirus, Integration of viral genome by retroviruses and spongiform encephalopathies caused by unconventional agents/viruses, such as BSE and scrapie.
持续性病毒感染的建立可被视为一种进化机制，以保护病毒免受宿主免疫反应的影响，并使病毒感染得以持续存在。原则上，在所有病毒科的大多数物种中都存在持续性或潜伏性病毒感染。在病毒感染过程中出现的不同策略中，本文选择并更详细地讨论了导致持续性或潜伏性感染的三种机制：阿留申病细小病毒对关键表位的掩盖及明显缺乏中和抗体、逆转录病毒对病毒基因组的整合，以及由非常规病原体/病毒（如牛海绵状脑病和羊瘙痒病）引起的海绵状脑病。
