泛醇与细胞色素c末端氧化酶的比较。另一种观点。

Comparison of ubiquinol and cytochrome c terminal oxidases. An alternative view.

作者信息

Musser S M, Stowell M H, Chan S I

机构信息

Arthur Amos Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena 91125.

出版信息

FEBS Lett. 1993 Jul 26;327(2):131-6. doi: 10.1016/0014-5793(93)80156-o.

DOI:10.1016/0014-5793(93)80156-o

PMID:8392948

Abstract

There have been numerous instances in the recent literature where the properties of ubiquinol and cytochrome c terminal oxidases are compared. Here we specifically examine the cytochrome bo3-type ubiquinol oxidase from Escherichia coli and the cytochrome aa3-type cytochrome c oxidases. A second redox-active copper site (CuA) is present only in the cytochrome c oxidases and the physiological electron donors for the two enzymes are different (ubiquinol-8 vs. ferrocytochrome c). In our opinion, these differences are significant and most likely indicate that distinct turnover mechanisms are operative in the two enzymes.

摘要

在最近的文献中有许多关于泛醇和细胞色素c末端氧化酶性质比较的实例。在这里，我们专门研究了来自大肠杆菌的细胞色素bo3型泛醇氧化酶和细胞色素aa3型细胞色素c氧化酶。第二个氧化还原活性铜位点（CuA）仅存在于细胞色素c氧化酶中，并且这两种酶的生理电子供体不同（泛醇-8与亚铁细胞色素c）。我们认为，这些差异很显著，很可能表明这两种酶存在不同的周转机制。