牙龈卟啉单胞菌诱导的中性粒细胞吞噬作用抑制与补体及免疫球蛋白G受体表达的变化
Changes in complement and immunoglobulin G receptor expression on neutrophils associated with Porphyromonas gingivalis-induced inhibition of phagocytosis.
作者信息
Tai H, Kobayashi T, Hara K
机构信息
Department of Periodontology, Niigata University School of Dentistry, Japan.
出版信息
Infect Immun. 1993 Aug;61(8):3533-5. doi: 10.1128/iai.61.8.3533-3535.1993.
Abstract
We examined the phagocytic capacity and receptor expression on neutrophils stimulated with Porphyromonas gingivalis soluble products. Stimulated neutrophils had decreased phagocytic capacities and altered expression of CR1, CR3, Fc gamma RII, and Fc gamma RIII. For cases in which TLCK (N-alpha-p-tosyl-L-lysine chloromethyl ketone) neutralized the effects of the stimuli, the P. gingivalis-derived factors causing the phenomena seem to be trypsin-like proteases.
摘要
我们检测了牙龈卟啉单胞菌可溶性产物刺激的中性粒细胞的吞噬能力和受体表达。受刺激的中性粒细胞吞噬能力下降，补体受体1（CR1）、补体受体3（CR3）、FcγRII和FcγRIII的表达发生改变。对于N-α-对甲苯磺酰-L-赖氨酸氯甲基酮（TLCK）中和刺激作用的情况，引起这些现象的牙龈卟啉单胞菌衍生因子似乎是类胰蛋白酶。
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