Role of Porphyromonas gingivalis-derived fibroblast-activating factor in bone resorption.
作者信息
Mihara J, Yoneda T, Holt S C
机构信息
Dentistry for the Handicapped, Osaka University Dental Hospital, Japan.
出版信息
Infect Immun. 1993 Aug;61(8):3562-4. doi: 10.1128/iai.61.8.3562-3564.1993.
Abstract
A 24-kDa protein was isolated from the outer membrane vesicles of Porphyromaonas gingivalis W50. This protein, referred to as fibroblast-activating factor (FAF), was examined for its bone-resorptive ability by the rat long-bone assay and the mouse bone marrow cell culture system. FAF resulted in a significant release of 45Ca from cultured bones, as well as the formation of tartrate-resistant acid phosphatase-positive monocytes. These cultures were compared with control cells. FAF therefore might be considered a significant bacterially expressed protein which could affect and modulate the resorption or destruction of tissue and alveolar bone in the local periodontal environment.
摘要
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