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Induction of high frequencies of endoreduplication in mammalian cell cultures with 33258 Hoechst and rubidazone.

作者信息

Kusyk C J, Hsu T C

出版信息

Cytogenet Cell Genet. 1979;23(1-2):39-43. doi: 10.1159/000131300.

DOI:10.1159/000131300
PMID:83930
Abstract

Cells of the mouse L strain and the Chinese hamster CHO line were treated with 33258 Hoechst, rubidazone, and a combination of these. Recovering cell populations following the drug removal exhibited a high frequency (20--50%) of metaphases with diplochromosomes (endoreduplication), especially in the combination treatment series (up to more than 70% in the L strain). Such a procedure should be useful in probing the mechanisms of the endoreduplication process.

摘要

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