p53抗原在原发性肝脏恶性上皮性肿瘤中的表达：一项免疫组织化学研究。

The expression of p53 antigen in primary malignant epithelial tumors of the liver: an immunohistochemical study.

作者信息

Choi S W, Hytiroglou P, Geller S A, Kim S M, Chung K W, Park D H, Theise N D, Thung S N

机构信息

Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, City University of New York, NY.

出版信息

Liver. 1993 Jun;13(3):172-6. doi: 10.1111/j.1600-0676.1993.tb00626.x.

DOI:10.1111/j.1600-0676.1993.tb00626.x

PMID:8393124

Abstract

We examined the expression of mutant p53 gene products in primary malignant epithelial tumors of the liver. Fourteen of 68 hepatocellular carcinomas, one of seven hepatoblastomas and one of nine intrahepatic cholangiocarcinomas showed nuclear staining for p53 proteins. None of the surrounding non-tumorous tissues expressed nuclear staining. The detection of p53 proteins in tumor cells was significantly higher in hepatocellular carcinomas of Oriental patients (31.6%) compared to non-Orientals (6.7%, p < 0.015). No significant differences were seen in p53 antigen expression between hepatitis B and non-hepatitis B associated hepatocellular carcinomas in Oriental patients. These results suggest a role for other environmental factors, such as aflatoxin, in the etiology of p53 mutation in hepatocellular carcinoma in Oriental patients.

摘要

我们检测了原发性肝脏恶性上皮性肿瘤中突变型p53基因产物的表达。68例肝细胞癌中有14例、7例肝母细胞瘤中有1例以及9例肝内胆管癌中有1例的p53蛋白呈核染色阳性。周围非肿瘤组织均未出现核染色。与非东方患者（6.7%，p<0.015）相比，东方患者肝细胞癌中肿瘤细胞p53蛋白的检出率显著更高（31.6%）。在东方患者中，乙型肝炎相关肝细胞癌与非乙型肝炎相关肝细胞癌之间的p53抗原表达未见显著差异。这些结果提示，黄曲霉毒素等其他环境因素在东方患者肝细胞癌p53突变的病因中发挥了作用。