结肠家族性腺瘤性息肉病中凹陷型微小腺瘤。通向普通息肉样腺瘤的一条途径。

Minute adenomas of the depressed type in familial adenomatous polyposis of the colon. A pathway to ordinary polypoid adenomas.

作者信息

Kubota O, Kino I

机构信息

First Department of Pathology, Hamamatsu University School of Medicine, Japan.

出版信息

Cancer. 1993 Aug 15;72(4):1159-64. doi: 10.1002/1097-0142(19930815)72:4<1159::aid-cncr2820720405>3.0.co;2-y.

DOI:10.1002/1097-0142(19930815)72:4<1159::aid-cncr2820720405>3.0.co;2-y

PMID:8393364

Abstract

BACKGROUND

It has been thought that colorectal adenomas are polypoid from their beginning. Although depressed adenomas have been described, they have been considered an unusual form and have not been studied systemically.

METHOD

More than 5000 colorectal adenomas in 24 resected large intestines of patients with familial adenomatous polyposis were examined by dissecting microscopic study. These adenomas were classified by their surface appearance as depressed, flat, or polypoid type. The frequencies and sizes of the three types were determined.

RESULTS

In addition to ordinary polypoid adenomas, many adenomas of the depressed type were found. Of the 5287 adenomas detected, 635 (12.0%) were depressed, 967 (18.3%) were flat, and 3685 (69.7%) were polypoid. Depressed adenomas constituted approximately 15% of all adenomas smaller than 1.5 mm diameter. However, they were rare in those of 1.5-2.0 mm diameter and were not found among those of more than 2.0 mm in diameter.

CONCLUSION

These findings suggest that some ordinary polypoid adenomas originate from minute depressed adenomas.

摘要

背景

一直以来人们认为结直肠腺瘤从一开始就是息肉样的。尽管已经有关于凹陷型腺瘤的描述，但它们被视为一种不常见的类型且未得到系统研究。

方法

通过解剖显微镜研究对24例家族性腺瘤性息肉病患者切除的大肠中的5000多个结直肠腺瘤进行了检查。这些腺瘤根据其表面外观分为凹陷型、平坦型或息肉样型。确定了这三种类型的频率和大小。

结果

除了普通的息肉样腺瘤外，还发现了许多凹陷型腺瘤。在检测到的5287个腺瘤中，635个（12.0%）为凹陷型，967个（18.3%）为平坦型，3685个（69.7%）为息肉样型。直径小于1.5毫米的所有腺瘤中，凹陷型腺瘤约占15%。然而，在直径为1.5 - 2.0毫米的腺瘤中很少见，在直径超过2.0毫米的腺瘤中未发现。