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Microwave-enhanced liquid-phase synthesis of thiohydantoins and thioxotetrahydropyrimidinones.微波增强硫代乙内酰脲和硫代四氢嘧啶酮的液相合成
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“多样体”：一种实现非肽、非寡聚化学多样性的方法。

"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.

作者信息

DeWitt S H, Kiely J S, Stankovic C J, Schroeder M C, Cody D M, Pavia M R

机构信息

Department of Chemistry, Warner-Lambert Co., Ann Arbor, MI 48106.

出版信息

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6909-13. doi: 10.1073/pnas.90.15.6909.

DOI:10.1073/pnas.90.15.6909
PMID:8394002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC47044/
Abstract

Solid-phase chemistry, organic synthesis, and an apparatus for multiple, simultaneous synthesis have been combined to generate libraries of organic compounds ("diversomers"). Arrays of compounds were synthesized over two to three steps incorporating chemically diverse building blocks on a polystyrene-based solid support in a multiple, simultaneous manner. The generality of this approach is illustrated by the syntheses of dipeptides, hydantoins, and benzodiazepines.

摘要

固相化学、有机合成以及一种用于多重同步合成的仪器已被结合起来，以生成有机化合物文库（“多样异构体”）。通过两到三步反应，以多重同步的方式在聚苯乙烯基固相载体上掺入化学性质各异的结构单元，合成了化合物阵列。二肽、乙内酰脲和苯二氮䓬的合成证明了这种方法的通用性。