乙内酰脲的组合化学
Combinatorial chemistry of hydantoins.
作者信息
Boeijen A, Kruijtzer J A, Liskamp R M
机构信息
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
出版信息
Bioorg Med Chem Lett. 1998 Sep 8;8(17):2375-80. doi: 10.1016/s0960-894x(98)00429-6.
PMID:9873544
Abstract
Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins. The preparation of trisubstituted hydantoins features a Mitsunobu reaction for introduction of the substituent on N-1.
摘要
通过方便且通用的方法进行3,5-、1,3-和1,3,5-取代乙内酰脲文库的固相合成，可实现乙内酰脲的组合化学。三取代乙内酰脲的制备以用于在N-1上引入取代基的Mitsunobu反应为特征。
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