肌醇脂质介导的核内信号传导：对干扰素α敏感和耐药的Daudi淋巴瘤细胞体内标记的比较分析。

Inositol lipid-mediated intranuclear signalling: a comparative analysis of in vivo labelling in interferon alpha-sensitive and -resistant Daudi lymphoma cells.

作者信息

Cataldi A, Di Primio R, Lisio R, Rana R A, Robuffo I, Bosco D, Miscia S

机构信息

Istituto di Morfologia Umana Normale, Università G. D'Annunzio, Chieti, Italy.

出版信息

Cell Signal. 1993 May;5(3):331-6. doi: 10.1016/0898-6568(93)90024-g.

DOI:10.1016/0898-6568(93)90024-g

Abstract

Changes in inositol lipid and diacylglycerol metabolism have been analysed in Daudi lymphoma cells treated up to 24 h with human DNA recombinant interferon alpha. Results showing a different response of nuclear phosphoinositides and diacylglycerol, compared to whole cells, suggest that the intranuclear signalling system activated by interferon in Daudi cells involves nuclear inositol lipid metabolism. A well-characterized clone of Daudi cells selected for resistance to the antiproliferative action of interferon provided controls for the specificity of results.

摘要

用人DNA重组干扰素α处理多达24小时的Daudi淋巴瘤细胞中，已对肌醇脂质和二酰基甘油代谢的变化进行了分析。与全细胞相比，结果显示核磷酸肌醇和二酰基甘油有不同的反应，这表明Daudi细胞中干扰素激活的核内信号系统涉及核肌醇脂质代谢。选择一个对干扰素抗增殖作用具有抗性的特征明确的Daudi细胞克隆作为结果特异性的对照。

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Inositol lipid-mediated intranuclear signalling: a comparative analysis of in vivo labelling in interferon alpha-sensitive and -resistant Daudi lymphoma cells.肌醇脂质介导的核内信号传导：对干扰素α敏感和耐药的Daudi淋巴瘤细胞体内标记的比较分析。

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