Gritters L S, Wahl R L
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
Oncology (Williston Park). 1993 Jul;7(7):59-63, 66 discussion 66, 69-70.
Although structural imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) have revolutionized the noninvasive assessment of visceral anatomy, significant difficulties remain in the diagnosis and surveillance of cancer. Differences in the metabolism and biochemistry of tumors, compared with normal tissues, are known to precede and are responsible for the changes in structural anatomy imaged by CT or MRI. Recent advances in nuclear imaging techniques utilizing single photon emission computed tomography (SPECT) provide improved 3D spatial resolution, compared with previous planar 2D nuclear imaging techniques. New techniques are also able to characterize differences in the biochemistry and functional metabolism of neoplastic tissue, compared with normal tissue. These new technologies offer potent advantages over previous nuclear imaging and structural imaging techniques, not only in the diagnosis of cancer but also as possible tools for monitoring and predicting the effects of therapy on cancer metabolism.
尽管计算机断层扫描（CT）和磁共振成像（MRI）等结构成像技术彻底改变了对内脏解剖结构的无创评估，但在癌症的诊断和监测方面仍存在重大困难。与正常组织相比，肿瘤的代谢和生物化学差异在CT或MRI成像的结构解剖变化之前就已存在，并导致了这些变化。与以前的平面二维核成像技术相比，利用单光子发射计算机断层扫描（SPECT）的核成像技术的最新进展提供了更高的三维空间分辨率。新技术还能够表征肿瘤组织与正常组织在生物化学和功能代谢方面的差异。这些新技术比以前的核成像和结构成像技术具有强大优势，不仅在癌症诊断方面，而且作为监测和预测治疗对癌症代谢影响的可能工具。
