一种转移性人乳腺肿瘤异种移植系的新型模型。
A novel model of a metastatic human breast tumour xenograft line.
作者信息
Hurst J, Maniar N, Tombarkiewicz J, Lucas F, Roberson C, Steplewski Z, James W, Perras J
机构信息
Goodwin Institute for Cancer Research, Inc., Plantation, Florida 33313.
出版信息
Br J Cancer. 1993 Aug;68(2):274-6. doi: 10.1038/bjc.1993.327.
Abstract
The GI-101 human breast tumour xenograft line is unique in that it spontaneously metastasizes to the lungs of athymic murine hosts from subcutaneous trochar implants. Both tumour and lung metastases are positive for normal human breast tissue markers. GI-101 also is positive for the p53 antigen but negative for the c-erbB-2 oncogene.
摘要
GI-101人乳腺肿瘤异种移植系的独特之处在于，将其通过皮下套管针植入无胸腺鼠宿主后，它会自发转移至肺部。肿瘤及肺转移灶的正常人类乳腺组织标志物均呈阳性。GI-101的p53抗原也呈阳性，但c-erbB-2癌基因呈阴性。
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