Berry J, van Gorp W G, Herzberg D S, Hinkin C, Boone K, Steinman L, Wilkins J N
Alcohol and Drug Treatment Program, West Los Angeles VA Medical Center, Brentwood Division, CA 90073.
Drug Alcohol Depend. 1993 May;32(3):231-7. doi: 10.1016/0376-8716(93)90087-7.
Sixteen subjects hospitalized for treatment of cocaine dependence were administered a battery of neuropsychological tests within 72 h of last cocaine use and again approximately 2 weeks later. Twenty-one non-cocaine using control subjects, matched for age, gender, ethnicity and education, also received neuropsychological testing. Abstinence from mood altering substances during the 2-week study period was verified for both groups on three occasions using quantitative urine analysis. The results suggest that recent cocaine use is associated with impairment in memory, visuospatial abilities, and concentration during the acute phase of withdrawal, independent of withdrawal-related depression. Furthermore, many of these deficits appear to persist at least 2 weeks beyond cessation of cocaine use.
16名因可卡因依赖住院治疗的受试者在最后一次使用可卡因后72小时内接受了一系列神经心理学测试，约两周后再次接受测试。21名年龄、性别、种族和教育程度相匹配的非可卡因使用对照受试者也接受了神经心理学测试。在为期2周的研究期间，通过定量尿液分析三次验证两组受试者是否戒除了改变情绪的物质。结果表明，近期使用可卡因与戒断急性期的记忆、视觉空间能力和注意力受损有关，与戒断相关的抑郁无关。此外，许多这些缺陷在停止使用可卡因后至少持续2周。
