Zappala A F, Post A
J Pharm Sci. 1977 Feb;66(2):292-3. doi: 10.1002/jps.2600660246.
A rapid near IR spectrophotometric method was developed for determining meprobamate in tablets, sustained-release capsules, suspensions, and injectables. The absorbance of a chloroform solution of the drug is obtained at about 1.96 mum for quantitation. Assay of nine commercial products from four different manufacturers gave results ranging from 97 to 104% of label claim. Coefficients of variation of 0.7 and 1.3% were obtained on the tablets and a sustained-release product, respectively.
开发了一种快速近红外分光光度法，用于测定片剂、缓释胶囊、混悬剂和注射剂中的眠尔通。该药物氯仿溶液在约1.96μm处的吸光度用于定量。对来自四个不同制造商的九种商业产品进行的测定结果为标示量的97%至104%。片剂和一种缓释产品的变异系数分别为0.7%和1.3%。
