Qadri S M, Ueno Y, Postle G, Tullo D, San Pedro J
Department of Pathology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Eur J Clin Microbiol Infect Dis. 1993 May;12(5):372-7. doi: 10.1007/BF01964437.
The antibacterial activity of the new fluoroquinolone rufloxacin (MF 934) was evaluated against 1095 clinical isolates and compared with that of other quinolones and various commonly used antibiotics. Rufloxacin was highly effective against members of the Enterobacteriaceae, inhibiting 98% of the isolates at a concentration of 1 mg/l. Ninety-two percent of Aeromonas hydrophila and 65% Acinetobacter strains tested were inhibited by 1 mg/l of rufloxacin, whereas 98% of methicillin-susceptible and 87% of methicillin-resistant Staphylococcus aureus strains and 76% of coagulase-negative staphylococci strains required 4 mg/l for growth inhibition. The MIC values of rufloxacin for most bacteria were 4-16 times higher than those of ciprofloxacin and norfloxacin. Rufloxacin had little activity against xanthomonads, pseudomonads and enterococci. Approximately 95-96% of isolates of Pseudomonas aeruginosa were inhibited by 2 mg/l of ciprofloxacin and norfloxacin as compared to 29% inhibited by rufloxacin at this concentration.
对新型氟喹诺酮类药物鲁氟沙星（MF 934）的抗菌活性进行了评估，以1095株临床分离菌为研究对象，并与其他喹诺酮类药物及各种常用抗生素进行比较。鲁氟沙星对肠杆菌科细菌具有高效抗菌活性，在浓度为1mg/l时可抑制98%的分离菌。1mg/l的鲁氟沙星可抑制92%的嗜水气单胞菌和65%的不动杆菌菌株，而对于甲氧西林敏感的金黄色葡萄球菌菌株，98%以及甲氧西林耐药的金黄色葡萄球菌菌株87%，还有76%的凝固酶阴性葡萄球菌菌株，需要4mg/l的浓度才能抑制其生长。鲁氟沙星对大多数细菌的最低抑菌浓度（MIC）值比环丙沙星和诺氟沙星高4至16倍。鲁氟沙星对黄单胞菌、假单胞菌和肠球菌几乎没有活性。浓度为2mg/l时，环丙沙星和诺氟沙星可抑制约95% - 96%的铜绿假单胞菌分离菌，而在此浓度下鲁氟沙星只能抑制29%的该菌分离菌。
