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Isozyme-selective cyclic nucleotide phosphodiesterase inhibitors: biochemistry, pharmacology and therapeutic potential in asthma.

作者信息

Raeburn D, Souness J E, Tomkinson A, Karlsson J A

机构信息

Rhône-Poulenc Rorer Ltd., Dagenham Research Centre, Dagenham, Essex, England.

出版信息

Prog Drug Res. 1993;40:9-32. doi: 10.1007/978-3-0348-7147-1_3.

DOI:10.1007/978-3-0348-7147-1_3
PMID:8395068
Abstract
摘要

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[Progress in the study of cyclic nucleotide phosphodiesterases].[环核苷酸磷酸二酯酶的研究进展]
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Characterization of ORG 20241, a combined phosphodiesterase IV/III cyclic nucleotide phosphodiesterase inhibitor for asthma.ORG 20241的特性，一种用于哮喘的磷酸二酯酶IV/III联合环核苷酸磷酸二酯酶抑制剂。
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Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?
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Effect of selective phosphodiesterase 3 inhibition on the early and late asthmatic responses to inhaled allergen.选择性磷酸二酯酶3抑制对吸入变应原诱发的哮喘早期和晚期反应的影响。
Br J Clin Pharmacol. 1998 Apr;45(4):387-91. doi: 10.1046/j.1365-2125.1998.t01-1-00689.x.
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Biochem J. 1997 Jan 1;321 ( Pt 1)(Pt 1):177-85. doi: 10.1042/bj3210177.
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Br J Pharmacol. 1996 Aug;118(8):2131-9. doi: 10.1111/j.1476-5381.1996.tb15653.x.
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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram.环磷酸腺苷特异性磷酸二酯酶强效选择性抑制剂RP 73401对嗜酸性粒细胞功能的抑制作用：与咯利普兰的比较
Br J Pharmacol. 1995 May;115(1):39-46. doi: 10.1111/j.1476-5381.1995.tb16317.x.