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[环核苷酸磷酸二酯酶的研究进展]

[Progress in the study of cyclic nucleotide phosphodiesterases].

作者信息

Zhou H L, Bian R L

机构信息

Division of Antiasthmatic Drug Research, Zhejiang Medical University, Hangzhou.

出版信息

Sheng Li Ke Xue Jin Zhan. 1995 Jul;26(3):213-7.

PMID:8584886
Abstract

There are five families of cyclic nucleotide phosphodiesterase isozymes, which have a common structure, but have different biochemical characteristics, physiologic functions and regulatory mechanisms. Various selective phosphodiesterase inhibitors may have potential uses for antiasthmatic, inotropic, vasodilative, antithrombotic and antidepressant drugs.

摘要

环核苷酸磷酸二酯酶同工酶有五个家族,它们具有共同的结构,但生化特性、生理功能和调节机制各不相同。各种选择性磷酸二酯酶抑制剂可能在抗哮喘、强心、血管舒张、抗血栓和抗抑郁药物方面有潜在用途。

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