Berberich W, Bier B, Schnabel K, Schlimmer P
Abteilung für Strahlentherapie, Radiologische Universitätsklinik, Homburg/Saar.
Strahlenther Onkol. 1993 Aug;169(8):469-75.
The study was performed for the evaluation of hyperfractionated radiotherapy in the treatment of non-small-cell lung cancer. From radiobiological data we expected that the twice daily irradiation with reduced single dose should result in a better sparing of the slowly proliferating healthy lung tissue without any loss in the tumoricidal effect. 34 patients were treated conventionally with 30 daily fractions of 2.0 Gy over six weeks and another 34 patients twice daily with 1.3 Gy over five weeks to a total dose of 65 Gy. The interval between two fractions lasted at least six hours. Life table (Kaplan-Meier estimate) indicated no contrast between the therapy schedules. The treatment groups did not differ in local response of the primary, progression-free interval and occurrence of distant metastases, the hyperfractionated schedule was very well tolerated. Comparison of the posttreatment quality of life showed a better course after the hyperfractionated regimen, without reaching a level of significance.
本研究旨在评估超分割放疗在非小细胞肺癌治疗中的效果。从放射生物学数据来看，我们预期每日两次照射且单次剂量降低，应能更好地保护增殖缓慢的健康肺组织，同时不影响肿瘤杀伤效果。34例患者接受常规治疗，在六周内每日照射30次，每次2.0 Gy；另外34例患者在五周内每日照射两次，每次1.3 Gy，总剂量为65 Gy。两次照射之间的间隔至少为6小时。生命表（Kaplan-Meier估计）显示两种治疗方案之间无差异。治疗组在原发灶局部反应、无进展生存期和远处转移发生率方面无差异，超分割方案耐受性良好。治疗后生活质量的比较显示，超分割方案后的情况较好，但未达到显著水平。
