Dagnault A, Deshaies Y, Richard D
Département de Physiologie, Faculté de Médicine, Université Laval, Québec, Canada.
Int J Obes Relat Metab Disord. 1993 Jul;17(7):367-73.
The effect of the 5-hydroxytryptamine agonist D,L-fenfluramine on energy balance was investigated in male and female rats in order to detect a possible gender difference. Male and female rats, either gonadally intact or castrated, received a daily injection of the 5-hydroxytryptamine (5HT) agonist fenfluramine during 28 days. Body weight and food intake were monitored throughout the treatment period. At the end of the treatment, rats were decapitated and their carcasses were processed in order to determine the carcass contents of energy, fat and protein. Regardless of the gender of the rats, fenfluramine significantly delayed the gains in body weight, body energy and body fat in either castrated or gonadally intact rats. In female rats, castration accelerated body weight gain in rats injected with saline as well as in those treated with fenfluramine. Additionally, castrated female rats deposited more energy, fat and protein than gonadally intact rats. In contrast, castrated male rats, independently of whether they received saline or fenfluramine, gained less body weight and deposited less energy, fat and protein than non-castrated male rats. In conclusion, the results of this study show that D,L-fenfluramine is as effective in altering energy balance in male as it is in female rats.
为了检测可能存在的性别差异，研究了5-羟色胺激动剂D，L-氟苯丙胺对雄性和雌性大鼠能量平衡的影响。完整或阉割的雄性和雌性大鼠在28天内每天注射5-羟色胺（5HT）激动剂氟苯丙胺。在整个治疗期间监测体重和食物摄入量。治疗结束时，将大鼠断头并处理其尸体，以确定尸体中的能量、脂肪和蛋白质含量。无论大鼠性别如何，氟苯丙胺均显著延迟了阉割或性腺完整大鼠的体重、身体能量和体脂增加。在雌性大鼠中，阉割加速了注射生理盐水以及接受氟苯丙胺治疗的大鼠的体重增加。此外，阉割的雌性大鼠比性腺完整的大鼠储存更多的能量、脂肪和蛋白质。相比之下，阉割的雄性大鼠，无论是否接受生理盐水或氟苯丙胺，其体重增加都比未阉割的雄性大鼠少，并且储存的能量、脂肪和蛋白质也更少。总之，本研究结果表明，D，L-氟苯丙胺在改变雄性大鼠能量平衡方面与雌性大鼠同样有效。
