Zenone T, Souquet P J, Michaud E, el Khoury M T, Demolombe-Rague S, Bady B, Pasquier J, Bernard J P
Service de Pneumologie, Centre Hospitalier Lyon-Sud, Pierre-Bénite.
Rev Med Interne. 1993 Jan;14(1):54-7. doi: 10.1016/s0248-8663(05)82526-3.
The authors report two cases of Lambert-Eaton myasthenic syndrome associated with small cell lung carcinoma. Following the observations, the clinical diagnosis of this syndrome is considered. We discuss the autoimmune pathogenesis and the relation between paraneoplastic syndrome and small cell cancer. This syndrome is caused by autoantibodies that block the voltage-dependent calcium channels at motor nerve terminals. Small cell carcinoma cells appear to express calcium channels, suggesting that autoantibody production may be triggered by tumor calcium channels determinants. The autoimmune paraneoplastic syndrome theory refers to cross-antigenicity.
作者报告了两例与小细胞肺癌相关的兰伯特-伊顿肌无力综合征病例。基于这些观察结果，对该综合征进行了临床诊断。我们讨论了自身免疫发病机制以及副肿瘤综合征与小细胞癌之间的关系。该综合征由阻断运动神经末梢电压依赖性钙通道的自身抗体引起。小细胞癌细胞似乎表达钙通道，这表明自身抗体的产生可能由肿瘤钙通道决定簇触发。自身免疫性副肿瘤综合征理论涉及交叉抗原性。
