Grussendorf-Conen E I
Hautklinik Medizinischen Fakultät RWTH Aachen.
Hautarzt. 1993 Jul;44(7):427-31.
During recent years, advances have been made in understanding the functions of the viral oncoproteins E6 and E7. E6 und E7 code for proteins forming complexes with cellular proteins, which regulate the cell cycle. This leads to a disturbance of the physiological control mechanism and to increased proliferation of the infected cells. Enhanced expression of viral oncogenes in cells infected by genital "high risk" HPV types results in chromosomal instability and in an accumulation of mutational events. Cutaneous HPV types apparently follow other strategies to transform their host cells.
近年来，在了解病毒癌蛋白E6和E7的功能方面取得了进展。E6和E7编码与细胞蛋白形成复合物的蛋白质，这些复合物调节细胞周期。这导致生理控制机制紊乱，受感染细胞的增殖增加。在感染生殖器“高危”HPV类型的细胞中，病毒癌基因的表达增强会导致染色体不稳定和突变事件的积累。皮肤HPV类型显然采用其他策略来转化其宿主细胞。
