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[Serological property of perchloric acid-soluble glycoprotein fractions of human meconium].

作者信息

Uchide N, Ohyama K, Yamakawa T, Watanabe H, Hirakawa S, Yoneyama K, Ohkuma S

机构信息

Department of Biochemistry, Tokyo College of Pharmacy, Japan.

出版信息

Yakugaku Zasshi. 1993 Jul;113(7):532-6. doi: 10.1248/yakushi1947.113.7_532.

DOI:10.1248/yakushi1947.113.7_532
PMID:8396178
Abstract

Perchloric acid-soluble fractions (PASFs) were separated, in yields of 87.0-151.9 mg per 1.0 g of wet meconium sample, from six samples of human meconium, and identified as glycoproteins having 41.2-74.1% carbohydrate by chemical composition analysis. Six PASFs reacted with anti-A, -B, -Lea and -Leb sera, but did not react with anti-M and -N sera. These PASFs alos reacted with many lectins such as DBA, UEA-I, Vicia graminea lectin (VGA), Vicia unijuga lectin (VUA), Con A, WGA, RCA-I, PHA-E, SBA, SJA, and influenza A and B viruses. The serological results show that six PASFs contained VGA or VUA-binding (Vgu) glycoproteins as new oncofetal substances, but did not contain M and N blood group substances.

摘要

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