Ikegami T, Oh H, Nakamura H, Asai T, Yoshida S
Second Department of Internal Medicine, School of Medicine, Chiba University.
Rinsho Ketsueki. 1993 Jun;34(6):773-5.
It has been reported that serum levels of thrombomodulin (TM) reflect endothelial damages in various diseases. We measured serum TM levels between day-10 and day 100 in 6 patients receiving allogeneic bone marrow transplantation. Serum TM levels were increased when patients had transplant related complications including graft versus host disease, hemorrhagic cystitis and interstitial pneumonitis. In patient without complications, serum TM levels were within normal limits. These results suggest that the serum TM level serves as a useful marker of treatment related toxicity and a predictor of complications after BMT.
据报道，血栓调节蛋白（TM）的血清水平反映了各种疾病中的内皮损伤。我们测量了6例接受异基因骨髓移植患者在第10天至第100天之间的血清TM水平。当患者出现与移植相关的并发症，包括移植物抗宿主病、出血性膀胱炎和间质性肺炎时，血清TM水平会升高。在没有并发症的患者中，血清TM水平在正常范围内。这些结果表明，血清TM水平可作为治疗相关毒性的有用标志物以及骨髓移植后并发症的预测指标。
