鸡重复1元件包含一个类多聚酶开放阅读框，属于反转录转座子的非长末端重复类。
Chicken repeat 1 elements contain a pol-like open reading frame and belong to the non-long terminal repeat class of retrotransposons.
作者信息
Burch J B, Davis D L, Haas N B
机构信息
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111.
出版信息
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8199-203. doi: 10.1073/pnas.90.17.8199.
Abstract
Chicken genomes contain approximately 30,000 chicken repeat 1 (CR1) elements scattered among single-copy sequences, but no information has yet been presented to account for how these elements could have dispersed. The fact that CR1 elements have common (although atypical) 3' ends and variable 5' truncations suggested to us that they might belong to the class of non-long terminal repeat retrotransposons that encode reverse transcriptases. From an analysis of unusually large CR1 elements, we now provide evidence for the presence of such a reverse transcriptase open reading frame. CR1 elements are distantly related to previously described non-long terminal repeat retrotransposons; however, we find that frog and torpedo ray genomes contain dispersed open reading frame segments that have > 50% identity to the CR1 open reading frame. This result suggests that CR1-like elements exist in several vertebrate classes that have evolved independently for approximately 400 million years.
摘要
鸡的基因组包含大约30,000个鸡重复序列1（CR1）元件，它们散布在单拷贝序列中，但尚未有信息说明这些元件是如何扩散的。CR1元件具有共同的（尽管是非典型的）3'末端和可变的5'截短这一事实向我们表明，它们可能属于编码逆转录酶的非长末端重复逆转座子类别。通过对异常大的CR1元件的分析，我们现在提供了存在这种逆转录酶开放阅读框的证据。CR1元件与先前描述的非长末端重复逆转座子有远缘关系；然而，我们发现青蛙和电鳐的基因组包含与CR1开放阅读框具有> 50％同一性的分散的开放阅读框片段。这一结果表明，类似CR1的元件存在于几个已经独立进化了约4亿年的脊椎动物类别中。
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Chicken repeat 1 elements contain a pol-like open reading frame and belong to the non-long terminal repeat class of retrotransposons.鸡重复1元件包含一个类多聚酶开放阅读框，属于反转录转座子的非长末端重复类。
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8199-203. doi: 10.1073/pnas.90.17.8199.
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